Bepotastine besilate is an antihistamine medication used for the treatment of allergic symptoms, particularly allergic rhinitis (hay fever) and allergic conjunctivitis (eye allergies).Bepotastine besilate works by blocking the effects of histamine, a substance in the body that is released during an allergic reaction. By inhibiting histamine, bepotastine besilate helps to relieve symptoms such as sneezing, itching, runny nose, and red, itchy, or watery eyes.