Atorvastatin calcium is a selective and competitive HMGCR (HMG-CoA reductase) inhibitor, the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Inhibition of HMG-CoA reductase leads to drastic reduction in cholesterol and other isoprenoids production. Competitive inhibitors of the reductase can induce the expression of LDL (Low Density Lipoprotein) receptors in the liver, that increases the plasma LDLs catabolism and lowers the cholesterols plasma concentration.
Bioavailability |
12% |
Molecular Formula |
C66H68CAF2N4O10 |
IUPAC Name |
(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihyd |
CAS Number |
134523-03-8 |
Bioavailability |
12% |
Molecular Formula |
C66H68CAF2N4O10 |
IUPAC Name |
(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihyd |
CAS Number |
134523-03-8 |